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HEXplorer: Scanning splice site sequence surroundings for splice enhancing/repressing properties
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12 months ago
caggtaagtat • 620

Hi everbody,

I would like to shortly introduce to you the tool my working group developed, the HEXplorer.

  • Helps you to check the sequence surrounding around 5' splice sites for splice enhancing or repressing Splice Regulatory Elements (SREs) nearby.

  • Visualizes the effect of point mutations on the SRP binding properties of a given genomic sequences

  • Calculates intrinsic strength of possible splice donors or acceptors (HBS and maxent score)

  • Validated through various point mutation analysis

You can find some background for the program in this paper.

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