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Protein MSA tools - Which is best for conserved domains and divergent protein extensions?

My question: Which Multiple Sequence Alignment method to use to align proteins with evolutionarily conserved domains and divergent (sometimes, structurally or with no structural data available) protein extensions?

Any tips/best practices on this topic? Is PRANK better than PROMALS3D better than MAFFT in this? Thanks!!

protein evolution promals3d alignment

Titles should be concise and to the point. Descriptions belong in the actual text. I've made some changes for you :-)

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