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Gene set analysis
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15 months ago

Hi! I have been very strict with my analyses and I have identified three short genomic regions (less than 1 Megabase) from several Genome Wide Association Studies. Very significant genes overlap with these regions, but few in number (around 30), even if I look 1 Megabase upstream and downstream. Running a gene-ontology enrichment analysis doesn't give good results, because only one gene of interest is usually involved. Can you suggest any tool or analysis which can be helpful in a similar situation, in order to identify relevant sets of biological pathways or functions? Please let me know. Thanks, cheers!

Genes Enrichment • 414 views
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We have absolutely no idea how you figured out those regions are relevant and on which biological question you are working, and as such, this is impossible to answer. If you write 'few in number' we have no idea whether that's 100, 10 or just 2. Be as informative as possible when asking questions.

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I have edited my question as suggested; thanks for the comment

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2.1 years ago
theobroma22 ♦ 1.1k

Since your GOIs are few in number you can manually get the sequence and just use BLASTX, then Uniprot or other to get more detailed info, no?

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Thanks; sounds reasonable!

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