So is there a tool that I can use to do this? I tried but doesn't work https://www.ncbi.nlm.nih.gov/homologene?cmd=Retrieve&dopt=MultipleAlignment&list_uids=2959
Conservation of amino acid
Hi all
How can I check if a given amino acid is conserved among species and get a table like this showing conservation? thank you
Helix A Helix B
Cyp40 273-306 LSCVLNIGACKLKMSNWQGAIDSCLEALELDPSN
FKBP51 317-350 LAAFLNLAMCYLKLREYTKAVECCDKALGLDSAN
FKBP52 319-352 LASHLNLAMCHLKLQAFSAAIESCNKALELDSNN
PP5 062-095 AIYYGNRSLAYLRTECYGYALGDATRAIELDKKY
Hop TPR1 038-071 HVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDW
Hop TPR2A 259-292 MTYITNQAAVYFEKGDYNKCRELCEKAIEVGREN
1 answer
By doing multiple sequence alignments and then looking for conserved residues at certain positions.
You need to save the sequence data (use download or send to file) and then use a tool like JalView, Clustal Omega or MEGA to do the multiple sequence alignment. These tools would then allow you to highlight conserved residues.
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