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Prediction of novel intronic SNP function?

I did my PhD few years back. I sequenced the seven coding exons of XLF (one of DNA repair genes) in 94 genomic DNA samples and found 2 SNPs already published in SNPdb and two novel. I'm looking for someone who could doing the prediction task to look the potential functions of these SNPs and of course he will be a coauthor.

snp snp alignment gene
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written by alemam.ahmed 0

Sorry, forget to mention that all the SNPs I found are intronic ones

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written by alemam.ahmed 0

Do you know if this SNPs would potentially bring to splicing variants?

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written by lessismore 144

Actually, I do not have much experience but I assume it potentially could

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written by alemam.ahmed 0

"he"? Only men then?

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written by Emily 2.4K

it was impersonal of course.

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written by lessismore 144

2 answers

If they are located next to the Exon junctions (2nt next) they could bring to intron retention

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written by lessismore 144

Thanks a lot lessismore for the suggestion. I think I should try to publish it as it is, Especially the gene resides on 2q35 where segmental duplication is a common occurrence.

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written by alemam.ahmed 0

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