Dear all I have some data of clinical isolates (bacteria). The data contains antibiotic name, isolate name, protein id against which its shows resistance and rate of resistance for strains of that clinical isolates. the data is like this and protein is in plasmid or chromosome.
vancomycin ecoli enzA 82%resistance rate, tested for 89 strains plasmid mediated chloroamphenicol E tnz 62%resistance rate, tested for 89 strains chromosome mediated
i want to calculate whether the resistance is increasing due to plasmid or chromosome.. Can anyone suggest me the statistical procedure to calculate it? What methods can be used for this purpose?
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sharmatina189059 •
1 answer
A simple approach to start with would be to do a chi-squared test of association between the two conditions (i.e plasmid vs chromosome) and the number of resistant strains. Then if a more refined analysis seems warranted, look at logistic regression.
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