Interaction calling using contact matrix

Question

[izzy.yichao.cai]

Hi all,

Does anyone get a clue on how to call chromatin interactions from a HiC contact matrix?

I found this useful software collection: https://www.4dnucleome.org/software.html . However, the most majority of them involved in mapping reads and generating/comparing contact matrix.

There are some tools to call intra-chromosomal interactions in R, but I want to call interactions globally all across the genome which include both intra- and inter-chromosomal interactions.

Thanks in advance!!