What package/function did you use? (don't know what XHMM is...). How does your data looks like? What code did you use that lead to this error? Please provide as much information as possible, and ideally, a minimum reproducible example. Not clear this is a bioinformatics question.

> XHMM_plots(PLOT_PATH,JOB_PREFICES,JOB_TARGETS_TO_GENES,SAMPLE_FEATURES)
Loading data from './DATA' XHMM run...
Read 2844 records
Read 7997 records
Reading 16 x 2844 named matrix
Reading 16 x 2420 named matrix
Read 0 records
Read 424 records
Reading 16 x 2420 named matrix
Reading 16 x 1 named matrix
Reading 16 x 16 named matrix
Read 1 record
Reading 16 x 2420 named matrix
Reading 16 x 2420 named matrix
Read 0 records
Read 0 records
Reading 16 x 2420 named matrix
Reading 16 x 2420 named matrix
Reading 16 x 2420 named matrix
Reading 16 x 2420 named matrix
Loading genes for dataset_1 targets
Error in heatmap.2(absCorrWithRemovedPC, Rowv = NA, Colv = NA, dendrogram = "none",  :
  `x' must be a numeric matrix

======================== I checked and compared the DATA files with other samples result, but the same step and parameter, it can run well in the other samples.....

Hello, maybe you have to load another library in R. library(gplots) library(plotrix) library(xhmmScripts) Try with these libraries loaded and maybe it will work. Regards Andrea