Hi All,

Suppose I only want to make the fast methylation-seq data alignment. Which tools or which kind of setting can give me fastest alignment to get the bam file?

for example, my fastq file is 400G, I just hope to finish the alignment within one day. I can only use the maxmimu multiple-core=32

Now, I use bismark. it is fast not I still few it takes too long time. For bismark, -L 32 -N 0 will make it faster. but just quite limited.

Thanks.