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In a induced pluripotency experiment, what happens to the cells that do not become pluripotent?

Hi all,

I am new to this topic, so please forgive me if this is a stupid question. The efficiency in a induced pluripotency experiment is usually very low, meaning that in these experiments a lot of cells do not become pluripotent. My questions is this: what happens to these cells? Do they basically remain unchanged (in terms of gene expression)? or do the gene expression levels change, but the change is not in a way that is required to give rise to pluripotency.

Thanks a lot.

induced pluripotency
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written by NPL • NPL

Questions on Biostars are expected to have some bioinformatics component. This question is purely about biology and will likely be closed due to this reason.

You should consider posting it over in biology stackexchange.

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written by GenoMax GenoMax

Hello mxb145!

We believe that this post does not fit the main topic of this site.

Not related to bioinformatics

For this reason we have closed your question. This allows us to keep the site focused on the topics that the community can help with.

If you disagree please tell us why in a reply below, we'll be happy to talk about it.

Cheers!

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written by WouterDeCoster WouterDeCoster

Those cells should die somehow, probably by apoptosis because they aren't pluripotent. That said, you are on a bioinformatics forum. I would suggest something like

for f in `cells/non-pluripotent-*`
do
kill -9 $f
done
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written by WouterDeCoster WouterDeCoster

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