I'm tired of seeing "blinded" questions, e.g. I have a sequence/stack of sequences, should/how can I do X and Y and Z?
Some posters neither explain why/what they really want from our advice nor give metadata relevant to the question, such as how many sequences, by what methods and from what organism. In such cases its difficult to tell if we are dealing with an honest neophyte who's supervisor has left them in the dark or an experienced commercial operator who wants to pump us for expertise while leaving us in the dark (but one can usually divine the difference)
I don't know what sticks or carrots we can offer to ameliorate this situation, but IMCO more transparency in this forum would really boost utility all-round (this includes declaring affiliation details in profiles).