FBA to simulate bacteria growth on different growth medium

Question

[cl10101]

FBA (flux balance analysis) is frequently used to simulate bacteria growth on different media (different growth medium). I wonder why just the information about presence of enzyme that metabolizes given substrat is not sufficient to assess if this substrat can be component of bacteria growth medium? Why we use FBA in this case?

[natasha.sernova]

See these articles:

From DNA to FBA: How to Build Your Own Genome-Scale Metabolic Model

http://journal.frontiersin.org/article/10.3389/fmicb.2016.00907/full

Detection of transcriptional triggers in the dynamics of microbial growth

Understanding carbon catabolite repression in Escherichia coli using quantitative models

https://nar.oxfordjournals.org/content/early/2012/05/24/nar.gks467.full

In the article above see the foolowing chapter, for example:

"Global transcriptional changes during growth on minimal and rich media"

http://dx.doi.org.sci-hub.cc/10.1016/j.tim.2014.11.002#

There is a chapter: "Flux balanceview"