Folks, I have the amino acid sequences identified for histidine kinases (HKs) and response regulators (RRs) coded in M. tuberculosis. Now, I need to identify the orthologous and paralogous genes for each HK and RR gene sequences of M. tuberculosis present across all the bacterial species. How should I do it (using BLASTp or whatever)?

PS: Please explain in all possible detail; I am not an expert in this Bioinformatics! :P