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Best way to determine if two groups of sequences are homologs?

Hello!

I had a question - what program/method would you use to determine if two groups of sequences (for example: group a with 7 sequences and group b with 6 sequences) are homologs? Would you use BLAST or ClustalOmega alignment? I think the thing is, I'm confused about which program is best and how to determine homology from that program.

Additionally - if not a bioinformatics program - what can you look for to determine homology?

Thank you so much for your help!

homologs fasta sequences

I moved this to a comment since the link to the documentation of ClustalX is not an answer for the question that the OP is asking. Original question suspiciously sounds like homework.

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