Is it possible to get LD statistics keeping haplotype in mind?

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7.7 years ago

QVINTVS_FABIVS_MAXIMVS ★ 2.5k

I have SHAPEIT haplotype scaffolds for a 1Mb region. I would like to determine the R2 of pairwises SNPs in a haplotype dependent manner.

Is there an option in PLINK that will produce LD statistics with haplotype in mind?

Or am I missing the point of LD and the results would be the same if the SNPs were not phased?

LD PLINK R2 Haplotype SHAPEIT • 1.8k views

ADD COMMENT • link 7.7 years ago by QVINTVS_FABIVS_MAXIMVS ★ 2.5k

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PLINK 1.x is not able to import phase information. LD statistics which take it into account will be a bit different.

ADD REPLY • link 7.7 years ago by chrchang523 10k

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Could you try separating the haplotypes into different plink files, then calculate it per (haplotype specific) plink file? You might have to do a lot of slicing and dicing, but you might be able to get it done this way.

ADD REPLY • link 7.7 years ago by LauferVA 4.2k

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