I am looking for a solid set of features that can be extracted from protein sequences. Ideally these features capture different, and diverse aspects of the chemistry of the proteins. I do not care about the specific features, - but I would need features / predictions, which are quite accepted.
While I noted that some webpages list collections of various bioinformatic tools for that purpose (e.g.: http://www.expasy.org/proteomics ) , I was wondering, which tools experienced bioinformaticians would consider to be trustworthy, useful and solid for general-purpose comparison on metazoan proteomes (especially if different tools seem to serve the same purpose)
1 answer
For example, see these sites:
http://www.ebi.ac.uk/Tools/pfa/
These tools below are for everything, find protein application in the middle:
You've asked for protein chemistry:
http://molbiol-tools.ca/Protein_Chemistry.htm
Human proteome and alternative splicing:
Distinct Types of Disorder in the Human Proteome: Functional Implications for Alternative Splicing
http://journals.plos.org/ploscompbiol/article?id=10.1371%2Fjournal.pcbi.1003030
Structural features. Old, but highly cited paper:
Structural Characterization of the Human Proteome
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187559/
and see these papers for protein - DNA interactions:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475627/
Extracting sequence features to predict protein–DNA interactions: a comparative study
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149858/
Absence of a simple code: how transcription factors read the genome
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