Hello

So lets say I have two samples under different conditions, S1 and S2. After running an RNAseq experiment I get these values

            S1        S2 
    Gene A  0         1.30564
    Gene B  2.75488   0

Calculating FC (S1/S2) I would either get 0 or an undefined value. I would like to use log2FC * Pvalue to rank my scores but I would get a 0 or still have a undefined. I know I can use the 0 values, but all FC in that situation will be weighed the same despite them being downregulated to different extents. I can't exactly exclude such data either because something important must be going on to turn on or off these genes entirely.

So what could be done to include this sort of data in my analysis?

Any advice will be appreciated. Thank you