I was asked to write down a short report on possible normalization and transformation methods that can be applied on GWAS data. Since I am new at GWAS data, I have any idea about these matters and I do not know which keywords must be searched.
Could you please give me some normalization or transformation method names or introduce text, article, etc. about it?
1 answer
See these posts:
A: GWAS dataset: SNPs with association p-value
A: I'm a new guy on GWAS data, what should I do?
and several papers below:
Effects of normalization on quantitative traits in association test
http://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-10-415
Genome-Wide Association Study of Metabolic Traits Reveals Novel Gene-Metabolite-Disease Links
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930510/
Genome-wide association analysis
http://www.stat-gen.org/tut/tut_analysis.html
Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain
http://www.sciencedirect.com/science/article/pii/S0969996112000915
Rank-Based Inverse Normal Transformations are Increasingly Used, But are They Merited?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921808/
[ Inverse Normal Transformation Of A Quantitative Trait In Gwas
this post discussed the same paper ]
For microarrays:
https://www.researchgate.net/publication/11014612_Microarray_Data_Normalization_and_Transformation
Disease case:
Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes
http://hmg.oxfordjournals.org/content/early/2013/10/08/hmg.ddt461.full
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