Hi,

I want to do allele specific binding analysis using ChIP-seq data but I have some problems with the first step: individualized genome construction.

In mouse, I found the vcf file with strain specificity like this format:

CHROM  POS     ID      REF     ALT     QUAL    FILTER  INFO    FORMAT  129P2   129S1   129S5   AKR     A_J     BALB    C3H     C57BL   CAST    CBA

Each strain have one annotation column but I failed to find this vcf file of zebrafish(danRer7). I only got three separate SNP vcf files each regarding one specific strain(AB_strain.vcf, Tu_strain.vcf, WIK_strain.vcf). I am wondering if I could just combine them using bcftools(merge). I am not so familiar with the SNP data so any advice would be helpful.

Thanks in advance.