GC content calculation for Genes

Question

[Pranavathiyani G]

I have a list of Human Genes(Gene Symbols: E.g.,-> PTEN, AASS, AATBC, AATF, QARS, ABAT, ACHE, etc), How can I find the GC content(%) of these genes? Is there any tool or database available?

I don't want to calculate by taking each gene sequence & to find the GC content. Is there any alternative way, a tool?

[natasha.sernova]

It has been already discussed in biostars.org

What Is The Gc-Content Across Different Human Chromosomes?

as well as in this paper:

http://courses.cs.washington.edu/courses/cse527/07au/notes/notes16.pdf

It was calculated for different chromosomes, but no tools were mentioned.

http://blog.kokocinski.net/index.php/gc-content-of-human-chromosomes?blog=2

[WouterDeCoster]

I think that throughout the gene body and exon intron structure your GC value will differ widely and as such a GC content per gene will be a meaningless trait... perhaps (depending on what you want to do) a sliding window approach is more appropriate.

[John]

This is hugely important. You really need to be sure that the term "gene" is meaningful given the context of your experiment. Fortunately, that link Devon gave you makes it really easy to slice and dice your regions with the filters :)

Answer 1

[Devon Ryan]

Because I'm nice, here is the biomart URL with the result for all human genes.

Answer 2

[mastal511]

You can get %GC from Biomart.