I need mutated breast cancer genes for my analysis. So I'm bit confused whether there is an existing database which consists of sequences having mutations in it. Is there any database to get the mutated & non-mutated gene sequence?
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Ahlam Ahmed •
Here are some related resources that are focused on somatic mutations in cancer:
DOCM - Database of Curated Mutations
CIViC - Clinical Interpretation of Variants in Cancer
BioStars post: CIViC - Clinical Interpretation of Variants in Cancer
BioStars post: Exploring cancer mutation data portals
Here is another generally relevant post: Database Of Tumor Suppressors And/Or Oncogenes
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Sean Davis
Thank you SEAN but, it doesn't contain information for many other genes like BRCA1 & BRCA2
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Ahlam Ahmed •
The databases I noted above are about somatic mutation, not germline mutation. Were you looking for somatic mutation databases or germline variants?
Dear Sean I'm looking for Ashkenazi mutations database 187_189delAG and 5382insC in BRCA1and 6174delT in BRCA2.
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Ahlam Ahmed •
Hi Sean, Does COSMIC have the information about somatic mutation ? Can you please point to the URL. I only found information at the gene level (cancer consensus genes). Thank you !!
PS: The link is here: http://cancer.sanger.ac.uk/cosmic/download
Here are few such databases:
Thnaks RAUNAK, but I didn't find any database about 187_189delAG and 5382insC in BRCA1and 6174delT in BRCA2.
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Ahlam Ahmed •
Newly released: jax.org/ckb
Perhaps not a direct answer, but take a look at:
https://github.com/seandavi/awesome-cancer-variant-databases
cBioPortal has mutation data for different cancer types including breast.
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