How do I calculate the confidence interval of a mutation rate?

Hi,

I am estimating the mutation rates (mutations/Mb) in a series liver tumors. How can I estimate the confidence interval of each mutation rate? I tried using the binomial test (binom.test function in R) but it is quite computation intensive...

Any better idea?

Thanks you very much in advance,

Eric

r genome sequence

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updated 4.1 years ago by Ram

• written 10.5 years ago by eric.letouze •

1 answer

The number of mutations per Mb follows a Poisson distribution. Here is a paper with 19 ways of computing a confidence interval for a Poisson mean.

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written 10.5 years ago by Jean-Karim Heriche

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