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How to perform correlation between unmatched miRNA and mRNA data?

How can we perform correlation analysis between unmatched microRNA and mRNA expression data?

Thanks in advance.

mrna correlation mirna integration
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updated by Ram 4.5K • | written by Masood 2

I think you should explain what you mean with 'unmatched', you can only calculate correlation on matching samples.

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written by 5utr 37

Thanks Gian for your reply.

You are right that we can only calculate correlation on matching data but in my case data is like following:

miRNA = 4 NormalSamples - 6 TumorSamples

mRNA_Gene = 4 NormalSamples - 5 TumorSamples

I want to calculate the inverse effect of miRNA on mRNA gene.

I have also asked similar sort of question with more detail but didn't got any reply yet.

Correlation of unmatched microRNA and mRNA expression data.

Thanks :)

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updated by Ram 4.5K • | written by Masood 2

First you need to exclude the samples that are not in both datasets and then you can calculate the correlation on the overlapping subset. Since you are using R you can merge the two matrix and then calculate Spearman correlation between all miRNAs and mRNA

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updated by Ram 4.5K • | written by 5utr 37

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