Can ABSOLUTE use bam file as input?

I want to use ABSOLUTE to infer tumor purity and ploidy, but I have a question for the input. Can ABSOLUTE work for WGS bams? If not, how can I convert the bam to the input needed by ABSOLUTE? http://www.broadinstitute.org/cancer/cga/absolute_run

tumor

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updated 4.0 years ago by Ram

• written 10.8 years ago by lyz10302012

1 answer

With WGS data, you need to provide absolute with segments, such as those obtained from hapseg.

Alternatively you could try my tool CELLULOID: tumor ploidy, cellularity, subclonal copy number events

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updated 6.7 years ago by Ram

• written 10.8 years ago by Lemire

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