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Tool/Packages for integrated DE expression analysis of Time course miRAN and mRNA ?

Hello guys,

I need any tool or R bioconductor packages for integrated DE expression analysis of miRAN and mRNA of time course data.

I have time course (4 time points with replicates[unfortunate not equally replicates from one time point to another]) expression matrix (transformed and normalized).

Thanks

mrna r mirna microarray

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