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Question about mutation spectrum

Hi all.

I am wondering how to calculate the mutation spectrum.

In paper, I found notations below which seem to refer the mutation spectrum.

C:G-> G:C

C:G -> T:A

C:G -> A:T (I skipped the all of the notations due to space)

My questions is as below.

  1. How to interpret notation above? what is meaning of colon? (for dividing?)
  2. Why the C,G and G,C (C:G -> G:C) is paired ? Is it convention?
  3. Finally How to calculate C/G->T/A?

I am looking forward to your kindly answer :)

genome next-gen-sequencing
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updated by Ram Ram • written by mangfu100 mangfu100

1 answer

The convention of reading is:

C:G > T:A means C is mutated to T and G is mutated to A, and so on for others.

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written by Chirag Nepal Chirag Nepal

Thanks for your reply.

To better understand, let me give an example.

the number of C->T mutations is 5 and the number of G->A mutations is 11.

than C:G->T:A is 16. Is that right?

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written by mangfu100 mangfu100

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