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Neep help understanding CYP genes nomenclature

I read this statement about CYP genes on http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/61241

Here is a Intermediate to extensive metabolizer: One copy of the CYP3A4*22 allele was detected. Therefore, this patient is expected to be an intermediate to extensive metabolizer. Reduced metabolism of drugs that are inactivated or activated by CYP3A4 is expected when compared to patients who are *1/*1.

What does patients who are *1/*1 mean?

cyp genetics
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updated by Ram Ram • written by iwegbue • iwegbue

1 answer

This isn't a bioinformatics question, but I'm not sure how easily you'll be able to find the answer via google. In short, the CYP family has its own specific nomenclature, with things like *22 being a specific genotype.

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updated by Ram Ram • written by Devon Ryan Devon Ryan

Thank you so much for replying my question, Devon. I think I may have figured it out.

*1/*1 refers to the 2 alleles of the SNP (in this case CYP3A4)

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updated by Ram Ram • written by iwegbue • iwegbue

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