Hi everyone,

I am having single end reads from Ion Torrent. I also did my de novo assembly with Spades (SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing) , MIRA and also I am using CISa : Contig Merger (http://sb.nhri.org.tw/CISA/en/Instruction) for single end reads.

Now if I merge the contig file from both the program which program I can use for this job?

After merging the contig the quality of draft genome will increase or not?

If any one have experience please help me out.

Thank you advance