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Markov chains from SAM pairwise alignment?

Hi all,

I was wondering if there is any tool that can obtain markov chains from a reference-guided SAM alignment or if that is even conceptually possible?

Thanks
Marc

next-gen

It's not clear to me what you are trying to achieve. Do you want to shuffle a sequence using a Markov process? Could you give an example of input and expected/desired output?

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