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is there any suitable drugs pathway analysis online tools?
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2.2 years ago
Mo • 880
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In my search, I could not find any easy to use and suitable online web. I have names of several drugs (only their names) I would like to know whether there is any tools that I can use for pathway analysis of them ? if so, which types of information can I obtain by using it?

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You said you have several drugs names. What is the purpose of finding pathway analysis in them??

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3.6 years ago
muratiskar • 20

You can have a look at Chemical Annotation Retrieval Toolkit available from:

http://cart.embl.de/

It matches an input list of chemical names to Pubchem IDs.

Later, bioactivity annotations (including pathways, protein targets) can be easily retrieved from CART.

Also, it is possible to perform chemical/drug annotation enrichment using the same toolkit.

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Thanks for pointing to this resource. Looks interesting!

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10 months ago
UK, Hinxton, EMBL-EBI

Try searching for the drug name in the Reactome database e.g. paracetamol. There is ChEMBL and ChEBI too but not sure if they provide pathway information but worth investigating them further.

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10 months ago
natasha.sernova ♦ 3.5k

It turned out, KEGG has a special site:

http://www.genome.jp/kegg/drug/

It provides pathways at the bottom of the corresponding pages, like this one:

http://www.kegg.jp/pathway/hsa05010

Also, try to look at close biostar-posts.

Is There A Free Alternative To Ingenuity Pathway Analysis?

Biological Pathways And Drug Designing

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20 months ago
Diwan • 560
United States

You can search for your drug in PubChem too. They have a section called "Biomolecular interaction and pathways".

For example, search for celecoxib: https://pubchem.ncbi.nlm.nih.gov/compound/2662#section=Biosystems-and-Pathways

(or) check NCBI Biosystems directly too. https://www.ncbi.nlm.nih.gov/biosystems

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