Tool: Discovering protein-lncRNA interactions from large-scale CLIP-Seq and TCGA Cancer datasets
We had released RBP-lncRNA Platform to decode interaction between lncRNAs and RNA-binding proteins (RBPs) by mining 111 CLIP-Seq (PAR-CLIP, HITS-CLIP, iCLIP, CLASH, eCLIP, irCLIP) datasets.
RBP-lncRNA platform provides the following Analysis Services:
- **We provide interactive web-page to display the 22,735 RBP-lncRNA regulatory relationships identified from 117 CLIP-Seq datasets generated by 50 independent studies.
- We also revealed the expression correlation of RBP-lncRNA interaction networks by mining expression profiles of over 6000 normal and tumor samples from 14 cancer types.
- We found that one single lncRNA will generally be bound and regulated by one or multiple RBPs, the combination of which may coordinately regulate gene expression.
- We discovered hundreds of disease-related single nucleotide polymorphisms (SNP) resided in the RBP binding sites of lncRNAs.
The paper has been published in Front Bioeng Biotechnol. 2015;2:88.
RBP-lncRNA Interaction web site: http://starbase.sysu.edu.cn/rbpClipRNA.php?source=lncRNA
RBP-lncRNA interactions are supported by co-expression analysis in 14 types of cancers.

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