Identify significantly mutated genes in mouse cancer genome

Hello, guys,

I want to identify the significantly mutated genes from several pieces of mouse cancer genome sequencing data. Do you know some software which could be used to do this? Like MutSigCV, which is only for human currently.

Best wishes,
Qingfei

gene mutation

• 2,242 views • link

updated 4.5 years ago by Ram

• written 11.7 years ago by jeefpan •

1 answer

Try Mutational Significance In Cancer (MuSiC) from WashU.

• 0 views • link

written 11.7 years ago by poisonAlien

More posts like this

How to determine subtype-specific mutations?
written 7.1 years ago by sugus

Hi there, We all know that given a profiling of gene expression data and two, maybe more, groups or subtypes, we could derive differentially expressed …
Enrichment Analysis with only GeneSymbols
written 7.5 years ago by hkarakurt

Hello everyone, I was looking to other posts but could not find a proper answer. I have a list of significantly changed genes and I …
Identifying driver mutations in mice cancer data
written 8.0 years ago by Gene_MMP8

I have 10 normal-tumor samples containing mice PDAC data. I have already called variants and annotated them. Now I wanted to use conventional driver mutation …
converting VCF to MAF fro mouse data
written 10.3 years ago by ksymeonidh •

Dear all, I am currently working on tumors from mouse data and I would like to run MuSiC in order to identify significantly mutated genes. …
Cancer-related and cancer "not-related" mutated genes
written 10.3 years ago by Bnf83

Hi guys, I'm wondering how many (%) genes in the genome carry mutations that are not cancer-related? Specifically...all we know that there are mutated genes …
Find unique genes in mouse genome with no homology to human genome.
written 10.8 years ago by Ron

Hi all, I have DNA sequencing data where human tumors have mouse reads as per the experiment protocol(similar to PDX). I have calculated the read …
MutSigCV output and coMut plots
written 12.0 years ago by A. Domingues

I am using the lastest MutSigCV v1.4, and trying to implement the ["CoMut plot"][1] to visualize the results. However, the [MutSigCv documenttation][2] only describes the …
Genome MuSic: Mutation frequency for single gene of interest across all available cancer types (pan…
written 12.0 years ago by atn3 •

I am interested in using Genome MuSic to analyze the mutation rate of a single gene of interest (ZBTB7A) across ALL cancer types (pan-can analysis) …
Converting Vcf File To Maf
written 13.1 years ago by l.pirhaji •

I'm going to use VarScan2 and MuSiC software to identify mutated genes from exome sequencing data. At first, I used VarScan2 to identity somatic mutations. …
Best Way To Do Pathway Analysis Of A Set Of Genes?
written 14.3 years ago by Wayne

What is the best way to do pathway analysis computational for a set of genes or proteins of interest. Specifically I am trying to identify …