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Gene interaction study?

I have two gene list. List1 with known disease gene; List2 with predictive disease causing genes. IS there any way by looking at interaction among these 2 gene list, I can short list my candidate genes?

gene interaction
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updated by theobroma22 theobroma22 • written by AP AP

Depends on what sort of interaction you're looking for (protein:protein, in a shared pathway, etc.). You'll need to provide us with more details.

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written by Devon Ryan Devon Ryan

Hi Devon,

i am mainly interested in studying protein protein interaction. Is there there any tool to look for shared pathway by the gene? Can you please let me how to do this also. This will add to my knowledge.

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written by AP AP

For finding genes in the same pathway, there probably are tools but I'd have to search to find them. It'd be easy enough to do that in R using the KEGG or reactome (or similar) databases. For protein:protein interactions, there may be tools for that too (I've never needed to do it, just google around). There are a number of databases to use for this, such as string.

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written by Devon Ryan Devon Ryan

1 answer

You could also try developing a co-expression network between the two lists.

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written by theobroma22 theobroma22

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