I have got the transcriptome of an organism whose genome has not yet been sequenced
I have done de novo assembly and annotation using online servers
How to check if the quality of assembly and annotation is good?
Can I align the transcriptome data against the genome of closely related organism
Is it good to perform functional genomics with the trasnscriptome annotated data
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lakshmi.bioinformatics •
Yes, you can align the transcriptome data against the genome of a closely related organism. You could in fact do that with the unassembled data and that should help you a lot with your other questions.
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Chris Evelo
+1 for alignment of unassembled reads.
For example, here is a paper describing such an application for a non-human primate.
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Charles Warden
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