Next generation sequencing variant calling pipeline

Question

[samuel]

Hi,

When designing a (germline or somatic) variant calling pipeline (e.g fastqs to vcf), could someone explain what the difference is between WGS vs WES vs panel sequencing bioinformatically?

Is the only difference that you pass the variant caller an interval list when calling exomes and/or panels? Or are there other major differences?

Am I missing something obvious?

Many thanks.