As we know ,there has differenct MSI-H prevalence for different cancer types . So if we wanna use NGS method to detect MSI status of tumor samples, should we consider to pick particular and specific MSI loci combination for one specific cancer ? and why ?
Becasue different cancers have different driver genes , should we choose MSI loci within the range of driver genes ? and why ?
what's the best method to pick MSI loci to determine the tumor sample MSI-H status ?
Any help is welcome !