GATK joint genotyping
0
0
Entering edit mode
6.2 years ago
win ▴ 980

Hi all, i am struggling a bit with preparing a cohort genome vcf file for joint genotyping using GATK.

I tried with 30 BAMs from 1000 genomes, and generated a single sample VCF for each, then used GATK CombineVariants and produced a "master" gVCF file.

This is not working during variant calling since it says the gVCF file is not valid.

Could someone please help in defining the right steps for generating a cohort gVCF file for use in GATK joint genotyping?

Thanks in advance.

GATK joint-genotyping NGS • 2.7k views
ADD COMMENT
0
Entering edit mode

Which version of GATK? What were the commands you used? Did you read the documentation (e.g here, here and here)? Did you name your gVCF as file.g.vcf?

ADD REPLY

Login before adding your answer.

Traffic: 2095 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6