Dear all, I am working on genetics risk score generation with many SNPs on certein diseases. Our previousl algorithm is based on weight GRS, however, without considering linkage disequilibrium. I would like to check the linkage disequilibrium between these SNPs and calculate the GRS with considering linkage disequilibrium. Is there any algorithm or paper could give me some idea on how to deal with this problem? Thanks and with best regards, Xinhui