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1
vote
5
replies
2.4k
views
Shannon vs Simpson for TCR diversity estimation
TCR
shannon
simpson
updated 28 days ago by
ATpoint
82k • written 5.1 years ago by
CY
▴ 750
0
votes
1
reply
184
views
How to reveal real AF of variant if duplicates can't be removed (such as in amplicon-seq)
allele-frequency
amplicon-seq
updated 28 days ago by
Ram
43k • written 28 days ago by
CY
▴ 750
2
votes
5
replies
3.9k
views
Any tools for predicting binding affinity between TCR and epitode?
prediction
TCR
cancer
updated 3 months ago by
tim
• 0 • written 5.9 years ago by
CY
▴ 750
2
votes
3
replies
984
views
Method to detect genome doubling
CNV
genome doubling
updated 17 days ago by
LauferVA
4.2k • written 4.5 years ago by
CY
▴ 750
2
votes
6
replies
1.7k
views
Can we get absolute abundance of TCR using TCR-Seq?
TCR-Seq
updated 15 months ago by
mizraelson
▴ 60 • written 5.4 years ago by
CY
▴ 750
0
votes
1
reply
1.6k
views
Wilcoxon test, t-test and negative binomial test for DEG of scRNA-Seq data
scRNA-Seq
DEG
differential expression
updated 18 months ago by
rpolicastro
13k • written 3.6 years ago by
CY
▴ 750
0
votes
0
replies
677
views
Why case-controlled study is more bias prone than cohort study?
case-controlled study
cohort study
confounder
written 3.5 years ago by
CY
▴ 750
0
votes
0
replies
329
views
Which distribution to choose for ploting mutant allele frequency?
distribution
SNV
18 months ago by
CY
▴ 750
0
votes
2
replies
3.7k
views
Comment:
Comment: Why NB distribution is preferred in RNA-Seq while normal distribution is preferr
24 months ago by
CY
▴ 750
0
votes
1
reply
508
views
Reference material for distinguishing focal CNV and chromosome CNV
CNV
updated 2.3 years ago by
German.M.Demidov
★ 2.9k • written 2.3 years ago by
CY
▴ 750
0
votes
1
reply
883
views
What is the well-recognized standard of coverage uniformity
sequencing
CNV
depth
uniformity
coverage
updated 2.8 years ago by
German.M.Demidov
★ 2.9k • written 2.8 years ago by
CY
▴ 750
0
votes
0
replies
1.1k
views
Comment:
Comment: Detection of CNV(InDel) of intermediate size
2.9 years ago by
CY
▴ 750
0
votes
1
reply
719
views
Detection of biallelic mutation (inactivation)
somatic
biallelic
mutation
updated 2.9 years ago by
Arsenal
▴ 160 • written 2.9 years ago by
CY
▴ 750
4
votes
2
replies
1.6k
views
Forum:
Why did expression based subtypng of breast cancer gain much more acceptance than others
RNA-Seq
subtyping
expression
updated 3.1 years ago by
GenoMax
142k • written 3.1 years ago by
CY
▴ 750
0
votes
0
replies
619
views
Comment:
C: Violation of Independence test for differential methylation (DM)
3.2 years ago by
CY
▴ 750
0
votes
2
replies
619
views
Violation of Independence test for differential methylation (DM)
methylation
differential methylation
3.2 years ago by
CY
▴ 750
3
votes
3
replies
1.3k
views
Treat methylation as binary or continuous signal when detecting DMR?
methylation
3.6 years ago by
CY
▴ 750
0
votes
1
reply
1.3k
views
Comment:
C: Treat methylation as binary or continuous signal when detecting DMR?
3.6 years ago by
CY
▴ 750
0
votes
1
reply
2.3k
views
Comment:
C: What statistical test for CpG DMR ?
3.7 years ago by
CY
▴ 750
5
votes
1
reply
1.2k
views
Is definition of differentially methylated region (DMR) biologically meaningful?
methylation
DMR
updated 3.7 years ago by
Hamid Ghaedi
3.2k • written 3.7 years ago by
CY
▴ 750
0
votes
2
replies
1.1k
views
Defining methylation level of CpG island
methylation
CpG island
3.7 years ago by
CY
▴ 750
0
votes
0
replies
1.1k
views
Comment:
C: Defining methylation level of CpG island
3.7 years ago by
CY
▴ 750
0
votes
1
reply
851
views
Comment:
C: How to derive sequence of novel transcript identified by Cufflinks
3.7 years ago by
CY
▴ 750
0
votes
3
replies
851
views
How to derive sequence of novel transcript identified by Cufflinks
transcript
RNA-Seq
3.7 years ago by
CY
▴ 750
0
votes
0
replies
493
views
Did and why recent studies show superior predictive power using methylation data on early cancer detection
methylation
cancer detection
3.8 years ago by
CY
▴ 750
0
votes
0
replies
669
views
Example code of MCMC on somatic variant calling (site specific error model)
Variant calling
3.9 years ago by
CY
▴ 750
0
votes
0
replies
474
views
Create synthetic data based on general description of molecular characteristic for modeling
next-gen
4.0 years ago by
CY
▴ 750
0
votes
0
replies
3.7k
views
Comment:
Comment: Why NB distribution is preferred in RNA-Seq while normal distribution is preferr
4.0 years ago by
CY
▴ 750
13
votes
9
replies
3.7k
views
Why NB distribution is preferred in RNA-Seq while normal distribution is preferred in microarray?
RNA-Seq
Microarray
updated 24 months ago by
dsull
★ 6.0k • written 4.0 years ago by
CY
▴ 750
0
votes
0
replies
999
views
Comment:
C: Logit-normal distribution to model variation among biological replicates
4.1 years ago by
CY
▴ 750
0
votes
2
replies
999
views
Logit-normal distribution to model variation among biological replicates
rMATS
alternative splicing
distribution
updated 4.1 years ago by
Kevin Blighe
87k • written 4.1 years ago by
CY
▴ 750
0
votes
1
reply
780
views
How does aligner determine strandness when doing alignment
alignment
4.2 years ago by
CY
▴ 750
0
votes
4
replies
1.1k
views
Would curated pathway gene set better being weighted than being binary
RNA-Seq
enrichment analysis
updated 4.2 years ago by
Biostar
20 • written 4.3 years ago by
CY
▴ 750
0
votes
1
reply
878
views
Comment:
C: Distinguishing real RNA-editing event from sequencing artifact due to reverse tr
4.2 years ago by
CY
▴ 750
0
votes
3
replies
878
views
Distinguishing real RNA-editing event from sequencing artifact due to reverse transcription
RNA-editing
sequencing artifact
4.2 years ago by
CY
▴ 750
1
vote
2
replies
1.1k
views
Detection of CNV(InDel) of intermediate size
CNV
InDel
2.9 years ago by
CY
▴ 750
2
votes
3
replies
992
views
Identifying zygosity of somatic deletion
CNV
updated 4.2 years ago by
bari.ballew
▴ 460 • written 4.2 years ago by
CY
▴ 750
0
votes
0
replies
992
views
Comment:
C: Identifying zygosity of somatic deletion
4.2 years ago by
CY
▴ 750
0
votes
1
reply
1.0k
views
Comment:
C: In PCA on RNA-Seq data, what does Gaussian distribution refer to?
4.3 years ago by
CY
▴ 750
0
votes
3
replies
1.0k
views
In PCA on RNA-Seq data, what does Gaussian distribution refer to?
RNA-Seq
PCA
Gaussian
updated 4.3 years ago by
Devon Ryan
104k • written 4.3 years ago by
CY
▴ 750
0
votes
1
reply
12k
views
Comment:
C: PCA vs ICA prior to t-SNE or UMAP
4.3 years ago by
CY
▴ 750
0
votes
1
reply
12k
views
Comment:
C: PCA vs ICA prior to t-SNE or UMAP
4.3 years ago by
CY
▴ 750
0
votes
2
replies
1.1k
views
Comment:
C: Would curated pathway gene set better being weighted than being binary
4.3 years ago by
CY
▴ 750
0
votes
0
replies
2.1k
views
Comment:
C: bwa XA field: What is the procedure for the binning of all but one alternative a
4.4 years ago by
CY
▴ 750
1
vote
1
reply
1.3k
views
Comment:
C: Arm-level SCNA does not change mRNA expression level?
4.4 years ago by
CY
▴ 750
0
votes
0
replies
920
views
Comment:
C: Does variant enrichment analysis make sense?
4.4 years ago by
CY
▴ 750
0
votes
2
replies
920
views
Does variant enrichment analysis make sense?
enrichment analysis
somatic variant
expression
4.4 years ago by
CY
▴ 750
6
votes
6
replies
1.3k
views
Arm-level SCNA does not change mRNA expression level?
CNV
SCNA
expression
4.4 years ago by
CY
▴ 750
2
votes
7
replies
1.3k
views
Why can we still be able to continuously discover new cancer driver bioinformatically these days?
driver gene
cancer
4.4 years ago by
CY
▴ 750
2
votes
0
replies
1.3k
views
Comment:
C: Arm-level SCNA does not change mRNA expression level?
4.5 years ago by
CY
▴ 750
276 results • Page
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