Hi, I'm a beginner in analyzing NGS data. This is my first time reading a paper. However I'm confused about the concept "Allelic ratio"
My question is: why the y-values (Allelic ratio) in the figure below are all between 0.2 and 0.8. Can "Allelic ratio" equal 1 in normal cells?
Figure legend: "Allelic ratio data of heterozygous loci in the normal genome are centered around 0.5, which represents the presence of two alleles". It's figure 1a in this paper.
Here is how I think about "Allelic ratio":
So, I think the ratio should be about 1 for a SNP genotype AA; 0.5 for AB; 0 for BB. But few points in this figure have a ratio more than 0.8 or less than 0.2, I'm confused about it.
Thank you for your help.