Entering edit mode
4.9 years ago
Hello...I´m kind of a newbie in bioinformatics and cancer biology in general. Many papers use the dn/ds method to test for natural selection in cancer genomes, and I have also used it, kind of following the notion of: If they do it they must have a reason. But now I face myself to the question of why? Why is dn/ds the method everybody chooses?
Some background reading:
Cancer Evolution Is Associated with Pervasive Positive Selection on Globally Expressed Genes
Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks
Universal Patterns of Selection in Cancer and Somatic Tissues