How to Simulate RNA-Seq data with allelic bias

Question

[Giovanni Quinones Valdez]

Hello everyone,

I am trying to simulate RNA-Seq reads to test some software. I want some of the genes to exhibit allele-specific expression, meaning to have one gene allele expressed more than the other. Is there a software that does such simulations?

Thanks,

PD. Also, if anyone knows of any software that also simulates RNA editing sites it would be great.

[nsmi8446]

If you're familiar with R this could be of value: http://www.bioconductor.org/packages/release/bioc/html/polyester.html