Do the gene sets of parent terms contains the gene sets of child terms in go ontology?
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5.3 years ago
xidianbill ▴ 10

What's the relationship of the gene set of the parent terms and the child term? For example, in the CC, term GO:0005737 is cytoplasm, and term GO: 0005739 is mitochondria. Do the genes of cytoplasm contains the genes of mitochondria? Is there any tools to let me get all genes in nuclear or cytoplasm?

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5.3 years ago

The Gene Ontology is a directed graph so terms inherit from all their children. For example, cytoplasm would inherit not just from "mitochondrion" but also from all other terms under "intracellular membrane-bounded organelle".
To get genes annotated with a GO term, you can use the go-perl modules or the R Bioconductor package topGO.

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