Protein binding domain database

Question

[yuabrahamliu]

I know some databases containing a great source of protein binding information, such as STRING and BIOGRID. But I found although these databases record the protein binding pairs, they don't have much information on the binding domain mediating the their binding, which might be useful when analyzing the influence of domain destruction on protein interaction. Is there any resource containing this kind of information? Thank you.

[natasha.sernova]

See this article.

iPfam: a database of protein family and domain interactions found in the Protein Data Bank

https://academic.oup.com/nar/article/42/D1/D364/1061536

iPfam looks helpful.

[Sishuo Wang]

Hi yuabrahamliu,

One way is to can try to collect all such domains, and search for them in databases like pfam, smart, etc. It might be time-consuming, though.