about inversions: head-to-head and tail-to-tail

Question

[Bogdan]

Dear all,

I would like to understand a bit better the differences between these 2 types of descriptions regarding the INVERSIONS :

a) tail-to-tail (3to3),

b) head-to-head (5to5)

as some SV callers list in the vcf file an INV either as a) or as b).

In some articles, i can see that the head-to-head inversion and tail-to-tall inversion define an INVERTED SEGMENT (for example in Supplem Data Table 5 : https://www.nature.com/articles/ncomms12605). thank you very much !

bogdan

[WouterDeCoster]

I'm confused, might be the anesthesia and painkillers from today, but doesn't each inversion have one 5-5 and one 3-3 breakpoint?

[Bogdan]

Hi Wouter, yes, indeed, each inversion has a 5-5 and a 3-3 breakpoint. My question was generated by the work on calling Structural Variants in cancer genomes, where an inversion was annotated either as "tail-to-tail (3to3)," or as "head-to-head (5to5)", likely due to the amount of evidence supporting either "tail-to-tail (3to3) breakpoint," or "head-to-head (5to5)" breakpoint.

[Shicheng Guo]

any update to the question?