Drug-Disease Pairs To Describe Drug Indications?

Question

[miquelduranfrigola]

Hi all,

I'm looking for a database that provides me with drug indications in the format of drug-disease pairs. As far as I know, DrugBank is not useful in this case because it gives ATC codes (which are difficult to map to disease terms, for instance, in MeSH terminology or ICD-10). PharmGKB is not useful either because it provides drug-disease pairs without specifying if the relationship corresponds to an indication or to an adverse event.

Thanks a lot!

Miquel

Answer 1

[Arnaud Ceol]

Hey Miquel,

the Therapeutic Target Database haa a drug-disease mapping file : bidd.nus.edu.sg/group/TTD/filedownload.asp?file=flatfiles/drug-disease_TTD2013.txt

[miquelduranfrigola]

Great, Arnaud! Thanks

Answer 2

[Malachi Griffith]

Some of the resources in this post may have some of this info:

Drug to Target/Gene/Protein Interaction Databases

Answer 3

[Diwan]

Apart from the links given above, check comparative toxicogenomics database (CTD) : http://ctdbase.org/ It gives the adverse effect (disease) associated with drugs/chemicals. The "direct evidence" ones have higher confidence.

Answer 4

[Emre]

Have a look at this: https://medschool.vanderbilt.edu/cpm/center-precision-medicine-blog/medi-ensemble-medication-indication-resource

MEDI (MEDication Indication) is an ensemble medication indication resource for primary and secondary uses of electronic medical record (EMR) data. MEDI was created based on multiple commonly used medication resources (RxNorm, MedlinePlus, SIDER 2, and Wikipedia) and by leveraging both ontology and natural language processing (NLP) techniques.