450k Methylation and Translocation

Question

[Tanvir Ahamed]

This is possible to identify translocation form 450k Methylation data ? Can anyone please explain why or why not this is possible ? Thanks !!

Answer 1

[Devon Ryan]

There's no way for a 450K methylation array to measure if signal happens to be from a translocated region or not. You'd need a completely different array to look at that, one designed specifically to look for translocations (it'd make more sense to just sequence to low depth).

[Tanvir Ahamed]

Thanks !! Devon Ryan.