Search for proteins with specific domain AND function

Question

[FX]

Is there a protein database/search engine where one can search for proteins containing specific domain (e.g. SET) and have a specific function (e.g. methyltransferase)?

Many thanks

Answer 1

[Pierre Lindenbaum]

uniprot query ( http://www.uniprot.org/help/query-fields ) : http://www.uniprot.org/uniprot/?query=go%3A0008168+AND+domain%3Aset&sort=score

[FX]

Many thanks for the hint. Exactly what I want.

Answer 2

[Jean-Karim Heriche]

PFAM, Ensembl (via BioMart or the API), UniProt and probably many others.

[FX]

Thank you for the links.