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8.3 years ago
J.F.Jiang
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910
Hi all,
I'm investigating the alleles of CYP2D6, in order to determine the activity of the drug metabolized.
As suggested by SNPedia and Wikipedia and other reports, different activities should be observed due to different variants.
It seems that each allele is determined by one/several variants, leading to CYP2D6*1/*4 diplotype.
My question is that if one contains more than 2 variants, how can we determine the alleles, such as rs1065852 lead to *10, rs5030655 leads to CYP2D6*6, rs3892097 leads to *4, since human is diploid.
Thanks
If a persons carry two heterozygous SNPs eg. rs1065852 and rs3892097, this person has probably the genotype
*CYP2D6**4*10. Perhaps this and that website will help you.Which alleles will the person carry if he owns three variants, leading to three alleles? Can this happen?
On the basis of simulation, it should happen.
Of course this can happen. If that pattern occurs in a population frequently (>1-5%), smart people will give this combination a new name. Otherwise this is a rare genotype. Haplotype analysis would be the next keyword.