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Have pathways a minimal significative size?
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2.8 years ago
fbrundu • 280
European Union

Hi all,

I am working on biological (specifically oncological) pathways and I would like to know if there is a minimal significative size for them.

Thanks

pathways size • 837 views
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17 months ago
Czech Republic, Brno, CEITEC

I believe that the size threshold is mostly selected empirically, e.g. more than 10-20 genes. You can have a look at curated oncological pathway signatures at MSigDB (http://www.broadinstitute.org/gsea/msigdb/collections.jsp#C6) to make an impression of their size and composition

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